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Lifestyle modifications : Patients who successfully implement and maintain dietary changes, physical activity routines, and behavioral strategies during treatment tend to experience less dramatic weight regain, though some regain typically still occurs

Emerging findings indicate that GLP-1 receptor agonists may influence neural and cognitive mechanisms underlying this phenomenon, including reward anticipation and cue reactivity, whereas mindfulness-based interventions appear to act on attentional regulation and aspects of DMN activity relevant to craving and rumination

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Patients carrying certain FTO (rs9939609) or MC4R (rs17782313) variants may experience different appetite-suppression intensity and gastrointestinal adaptation timelines