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Safety Considerations Common Side Effects Nausea, vomiting, diarrhea, decreased appetite, constipation, and abdominal pain Injection site reactions (redness, itching, swelling) Hypoglycemia (especially if used with insulin or sulfonylureas) Serious Risks Pancreatitis: Seek immediate medical attention for severe abdominal pain

[55] A randomized, double-blind, placebo-controlled study from 2006 assigned participants to one of four groups for the 12 week study period besides the placebo group, one got grapefruit juice, another fresh grapefruit, and finally, the fourth group took capsules continuing grapefruit extract

It may even help with addiction, according to other research and anecdotal reports

Beta-cell mass in obesity and type 2 diabetes, and its relation to pancreas fat: a mini-review