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Semaglutide produces a relatively narrow peak-to-trough ratio because of its long seven-day half-life

Due to their large molecular weight and hydrophilic nature, GLP1 agonists face challenges with oral delivery, including poor and variable gastrointestinal absorption, leading to low bioavailability

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These trials have enriched the therapeutic landscape for T2D patients, offering a range of GLP-1 receptor agonists with varying cardiovascular profiles, thus allowing clinicians to personalize treatment for each patient