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Co-cultures of microglia and/or astrocytes with neuronal cell lines, such as the human neuroblastoma SH-SY5Y cells and the Lund human mesencephalic (LUHMES) cells, have also been employed to closely mimic the physiological environment of neurons in the human brain, providing a more relevant system to study the effect of microglia NLRP3 activation (Sherer et al., 2002

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coverage pathways may differ