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The active forms of endogenous GLP-1 are primarily GLP-1(7-36) amide and, to a lesser extent, GLP-1(7-37)
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Switching, Combining, and Monitoring Questions Switching from semaglutide to retatrutide is not a standard routine-care step because retatrutide remains investigational in the evidence discussed here
Similar patterns emerge with tirzepatide, though longer-term discontinuation data remains limited
