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The dosing formulation protocol, the route of administration, dose volumes, and the timing of dosing were the same in both of experiments

Our observations about the efficacy of GLP-1 RAs in enhancing survival and reducing cardiovascular events are concordance with evidence from several cardiovascular outcome trials (CVOTs) conducted in general population with T2DM, as well as a recent cohort study focused on solid organ transplant recipients [16,17,18,19, 23]

The detailed subgroup analysis of different GLP-1 RA groups compared to non-GLP-1 RA users is demonstrated in Table 4

Heart Failure Outcomes GLP-1 agonists show promise in heart failure, particularly HFpEF, as follows: STEP-HFpEF and STEP-HFpEF DM: Semaglutide improved KCCQ scores (+16.6 points), reduced HF hospitalizations (HR 0.79), and enhanced physical function in HFpEF patients with or without T2DM [11,46]