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Initially, GLP-1s were developed to treat type 2 diabetes and were marketed for that purpose under brand names such as Ozempic (semaglutide), Rybelsus (semaglutide), Victoza (liraglutide), and Mounjaro (tirzepatide)

6) Consider OTC options with clinician guidance Lifestyle steps are first-line for many people

Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

These drugs need to be used in combination with healthy eating and exercise, not only because reduced intake is one of the main mechanisms by which the drugs help with weight loss, but also because healthy habits and sustainable lifestyle changes are essential to maintain weight loss once drug treatment is discontinued