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They are generally avoided in people with a personal or family history of medullary thyroid cancer or MEN2 syndrome, a history of pancreatitis, severe gastroparesis, or during pregnancy and breastfeeding, and they require caution in significant kidney or liver disease
This can increase the severity of SA through alterations upper airway inflammation and neuromuscular function, arousal mechanisms, and sleep architecture [53]
However, the majority of this research has studied oral administration (pills, capsules) rather than transdermal delivery
HPLC traces
