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GLP-1 receptor agonists have become a cornerstone of modern weight management, but they aren't prescribed to everyone

But the core molecule is now public property in most of the world, and the $26 billion business built on it will look very different by 2033

From the approval of Orlistat (Xenical) in 1999, which focused on reducing dietary fat absorption, to the emergence of highly effective incretin-based therapies such as liraglutide (Saxenda), semaglutide (Wegovy), and tirzepatide (Zepbound), we have witnessed a fundamental shift in how obesity is understood and treated

Semaglutide injections can be used for extended periods when medically appropriate, with most patients benefiting from continuous therapy to maintain weight loss results