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Food and Drug Administration (FDA) approves Eli Lillys Mounjaro (tirzepatide) for treatment in adults with Type 2 diabetes
But the Centers for Medicare & Medicaid Services (CMS) has the authority to test coverage changes through Center for Medicare and Medicaid Innovation (CMMI) models and other statutory demonstration authorities

Shin AS, Camilleri M
In the brain, impaired insulin signaling alters phosphorylation of insulin receptor substrate (IRS) proteins in the substantia nigra, disrupting mitochondrial proteins, calcium homeostasis, and mitochondrial biogenesis [26-30]
