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doi: 10.1007/s40267-021-00853-y 96 NiemanLKBoscaroMScaroniCMDeutschbeinTMezosiEDriessensNet al

Comprehensive Improvement of Metabolic Syndrome In addition to its core glucose-lowering and weight-loss effects, this drug also provides additional benefits such as lower systolic blood pressure, improved lipid profile (reduction in total cholesterol and triglycerides), and improvement of non-alcoholic fatty liver disease

This suggests that these genetic variantsmay promote a shift toward dysfunctional states (Khetan et al., 2021)

The Phase 2 trial included DEXA scans to measure changes in fat mass and lean mass
