mechanism of action of glp-1 receptor agonist What is and Its Agonists? Frontiers | GLP−1 receptor agonists

These data suggest a potential for long-term benefit of liraglutide treatment in many patients, as weight loss of 515% has been shown to improve obesity-related complications including diabetes and cardiovascular disease risk factors [5, 9, 59]

For example, different actions of GLP-1 receptor agonists such as delaying gastric emptying which leads to a prolonged feeling of fullness and reducing food intake lead to significant weight loss ( Endogenous GLP-1 has a short half-life since it is in 1-2 minutes degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

Dankner R, Roth J

Russell-Jones D, Cuddihy RM, Hanefeld M, Kumar A, Gonzalez JG, Chan M, et al