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These side effects usually ease within the first couple of weeks as your digestive system becomes more accustomed to the treatment

Instead, they've created a robust framework built on principles and categories

A 2025 clinical study in women with PCOS and obesity (n=56) found tirzepatide led to significant weight reduction (mean 9.54%) and improvement in menstrual regularity: irregular cycles decreased from 85.7% before treatment to 32.1% after

This metabolic shift is beneficial for weight loss, but it creates a nutritional challenge: your body still needs adequate protein to maintain muscle tissue, support immune function, and regulate blood sugar