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Carriers of certain GIPR variants may have baseline differences in GIP signaling capacity

These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

Morning dosing before breakfast is typically easier to remember than evening administration

Fiber can change absorption of some drugs and additive gastrointestinal effects may occur