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349,350 At the same time, the levels of two important components of the cartilage matrix, proteoglycans (a large molecule and a major component of the cartilage matrix) and type II collagen (the main structural protein of cartilage), increased

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Oral administration of US FDA approved DPP-4 inhibitors, such as Saxagliptin, Vildagliptin, Anagliptin, etc., prolongs the half-lives and thus the action of GLP-1 and GIP, which in turn improves glycemic control with minimal risk of hypoglycemia (Havale and Pal, 2009)

The qualifying diagnoses (HFpEF, uncontrolled hypertension, CKD, pre-diabetes, prior MI, prior stroke, PAD) are the conditions where GLP-1 trials have shown direct benefit or strong biological plausibility for benefit