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"Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes." International journal of molecular medicine 22.2 (2008): 229-236

The ideal candidate is someone who has a meaningful fat-loss goal, defined as 20 lbs or more to reduce, who is also concerned about how skin quality and connective tissue integrity will hold up through that process

The trials were conducted by randomly dividing people into different treatment groups receiving either clomiphene citrate or letrozole along with NAC or a placebo to compare the effectiveness of NAC (Table 1)