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In addition, the increasing of oxidative and nitrosative stress in the heart during aging and the decreasing of hydrogen sulfide (H 2 S) concentration along with a decline of a constitutive synthesis of nitric oxide (NO) collectively lead to the dysfunction of mitochondrial mechanisms, in particular to the formation of a non-selective channelsthe mitochondrial permeability transition pores (mPTP) in the high-conductance mode, which is the cause of many pathological conditions (Strutynska et al., 2016

W.JiangF.ChenY.YamamotoK

The mitochondria used in the study were isolated from the heart of inducible Coq7 knockout (KO) mice (123)

Curr Pediatr Rev