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A subsequent study revealed that CoCl 2 pretreatment protected auditory hair cells (HEI-OC1) from H 2 O 2 -mediated cytotoxicity via the activation of the redox-sensitive transcription factors HIF-1 and NRF2, as well as their target gene PRDX6 , indicating the protective roles of antioxidant enzymes against noise-triggered oxidative damage [136]
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Glutathione also participates in fatty acid synthesis and amino acid transport across the cell membrane.[1]
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