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However, Margaret McCarthys lab has shown that drug-mediated inhibition of prostaglandin synthesis (as is accomplished by acetaminophen) in laboratory rats during a time sensitive window in early postnatal life not only results in significant long-term modifications to brain development and morphology but also leads to decreased social interactions and reduced sensory function in male but not female animals

Antioxidant defense system The effect of ROS is limited by the presence of various regulatory systems that maintain redox homeostasis

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IAV infection has also been shown to suppress glucose-6-phosphate dehydrogenase expression, leading to decreased Nrf2 expression, induction of oxidative stress, and viral replication 70