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We determined whether peripheral semaglutide affected reward collection and VTA dopamine-neuron activity related to food-predictive cues and sucrose rewards in mice

Animals were maintained on this diet for 6 weeks, after which they underwent baseline screening for the study with an additional physical examination, metabolic and safety clinical chemistry profiling, hematology, and DXA for body composition

We need well-designed, long-term clinical trials to determine whether these drugs can be effectively used to preserve cognitive function or even treat neurodegenerative conditions like Alzheimers disease, Merrill emphasized.

GLP-1, Bile Acids and Fat Absorption Recent studies show that GLP-1 agonists modulate bile acid metabolism by increasing the growth of gut bacteria that deconjugate bile acids